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10.24875/RIC.20000208 59 Vidal-AlaballJ.ButlerC

In cases of suspected cobalt hypersensitivity, an intradermal test dose should be administered

For this reason, drugs with a long half-life (e.g., amiodarone, elimination t 1/2 of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly