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In addition, through transplantation of PSP-associated intestinal flora, could also increase the expression of TJ proteins, reduce LPS, and inhibit inflammatory responses in the hippocampal area, and alleviate depression, effects similar to that of direct administration of PSP (Table 2)

Studies have mainly explored the regulatory effects of AS-IV on fibrosis from the perspectives of experimental animal models at the cellular, molecular and genetic levels, with most only focusing on single drug components and large-sample placebo-controlled, randomized and standardized double-blind experimental data regarding TCM treatments awaiting further investigation (10,14)