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These compounds increase levels of phase II detoxifying enzymes, inhibit the activities of cytochrome P450 enzymes that activate carcinogens, modulate the Nrf2 pathway, and initiate apoptosis and cell cycle arrest in various cancer cell lines ( 3.3 Gut microbiome modulation The gut microbiome, a complex community of trillions of microorganisms living in the human digestive tract recently recognized as one of the main mediators of the beneficial effects of plant-based dietary patterns ( Faecalibacterium prausnitzii , Roseburia intestinalis , Bifidobacterium longum , Lactobacillus species, and members of the Ruminococcaceae family, which collectively synthesize short-chain fatty acids, mainly butyrate, propionate, and acetate, as their principal fermentation metabolic products ( Faecalibacterium and Bifidobacterium

492 The diversity and complexity of p53 mutants pose significant challenges for targeted therapies

Taurine deficiency can lead to retinal degeneration, which may manifest as poor vision or blindness

For example, children less than 4 years of age may be considered too young to properly utilize a self-report pain scale

doi: 10.1007/s00431-003-1177-z

In-vivo buccal delivery of fluorescein isothiocyanatedextran 4400 with glycodeoxycholate as an absorption enhancer in pigs