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Glossary AHR Aryl Hydrocarbon Receptor AMPK AMP-activated protein kinase AP-1 Activator proten-1 APCs Antigen-presenting cells ARE Antioxidant response element ATP Adenosine triphosphate BHLHE40 Basic Helix-Loop-Helix Family Member E40 Blimp-1 B lymphocyte-induced maturation protein-1 Eomes Eomesodermin ER Endoplasmic Reticulum ETC Electron transport chain FAS Fas Cell Surface Death Receptor FPR1/2 Formyl peptide receptors 1 and 2 CAT Catalase CD Crohns disease CTLs Cytotoxic T-lymphocytes DCs Dendritic cells ER Endoplasmic reticulum ERK Extracellular signal regulated kinase ETC Electron transport chain FAO Fatty acid oxidation FcR I/FcR III Fc receptors for IgG I/III FFAR Free fatty acid receptor GI Gastrointestinal GLLC Glutamate-cysteine ligase catalytic GM Gut Microbiota GPR G-protein receptors GPR109A G-protein-coupled receptor GPx Glutathione peroxidase GR Glutathione reductase GSH Glutathione GST Glutathione- S-S-Transferase H 2 O 2 Hydrogen peroxide H3K9ac Histone H3 acetylated in lysine 9 H 2 S Hydrogen sulfide HDAC Histone deacetylase HIF-1 Hypoxia includible factor-1 IBD Inflammatory bowel disease IL-2 Interleukin-2 ILCs Innate lymphoid cells iNKT Invariant natural killer cells JNK c-Jun N-terminal kinase Keap1 Kelch-like ECH-associated protein 1 LCA Lithocholic acid MAIT Mucosal associated invariant T-cells MAPK Mitogen activated protein kinase MEK Mitogen activated kinase MF Myofibroblasts MS Multiple sclerosis mTOR mammalian Target of Rapamycin NAC N-acetyl cysteine NF-B Nuclear factor-kappa B NFAT Nuclear factor of activated T-cells NK Natural killer cells NO Nitric oxide NOS N 2 O: Nitrous oxide NOS Nitric oxide synthase NOX NADPH oxidases NOX-2 NADPH oxidase 2 NRF-2 Nuclear factor erythroid-2-related factor 2 Nur77 Nuclear receptor subfamily 4 group A member 1 OXPHOS Oxidative phosphorylation PD-L1 Programmed death ligand 1 PI3K Phosphoinositide 3-kinases PKC Protein kinase C PPP Pentose phosphate pathway RA Rheumatoid arthritis RAS Rat sarcoma virus protein RAF Rapidly accelerated fibrosarcoma protein ROS Reactive oxygen species RNS Reactive nitrogen species Runx3 RUNX Family Transcription Factor 3 SCAFs Short-chain fatty acids SFB Segmented filamentous bacteria SMC Smooth muscle cells SOD Superoxide dismutase Sp1/Sp3 Specificity protein 1 and 3 TAK1 TGF-activated kinase 1 TCM Central memory T-cells TCR T-cell receptor TEM Effector memory T-cells Tfh T-follicular helper cells TRM Tissue resident memory T-cells Tregs Regulatory T-cells TRX Thioredoxin Trx/TrxR Thioredoxin/thioredoxin reductase UC Ulcerative colitis References 1 HildemanDAMitchellTKapplerJMarrackP

Role of ascorbic acid in scavenging free radicals and lead toxicity from biosystems

Douglass, J., Weiss, K

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These and many other studies have demonstrated that raised lactate in the context of trauma, sepsis and critical illness generally is a poor prognostic sign indicating the need for immediate and intensive resuscitative measures

Data were collected from at least 10,000 cells