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Statements Author contributions QW: Data curation, Investigation, Writing original draft

Determination of initial turnover number The initial turnover rates were determined in PBS at pH 7.4 (8 g l 1 NaCl (Labkem, SOCH-00T), 1.44 g l 1 Na 2 HPO 4 (Supelco, 1.06586), 0.2 g l 1 KCl (Panreac, 131494) and 0.24 g l 1 KH 2 PO 4 (Fisher Scientific, BP362)) using ABTS (1 mM), DMP (5 mM), guaiacol (50 mM), sinapic acid (0.35 mM) or p -coumaric acid (0.1 mM) as substrate

NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy

Nat Commun 5:4029

Early or excessive use of antibiotics can disrupt the gut microbiota, increasing the risk of diseases such as asthma and allergic rhinitis (Mitre et al., 2018)