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Ethacraplatin a dual-threat platinum (IV) prodrug is a cisplatin molecule coordinated to two ethacrynic acid ligands which is able to inhibit irreversibly GSTP1-1 enzymatic activity being reduced and cleaved as a consequence of binding (Fig

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15 Thus, as demonstrated in the current case, early detection of neurologic deficits is critical because they may be at least partially vitamin B 12 supplementation can at least partially reverse neurologic deficits

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