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Besides stability, linkers also play a significant role in the physicochemical properties of ADCs

these often resolve within hours to days

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Furthermore, we observed a reduction of intracellular ROS in metZ upon methionine supplementation at pH 7.2, while this effect was less pronounced at pH 5.5 (Fig

These conditions share common pathologies, including progressive loss of neurons, oxidative stress, impaired DNA repair, and abnormal protein aggregation

The anti-iNOS antibody (#ab15323) was obtained from Abcam (Cambridge, UK), the anti-PDI antibody (#3501S) from Cell Signaling Technology (Boston, Massachusetts, USA), the primary anti-CYP2E1 antibody (#A22629) from ABclonal (Wuhan, China), the anti--actin antibody (#GB15001) and the HRP conjugated goat anti-mouse IgG (H + L) (#gb23301) from ServiceBio (Wuhan, China), and the rabbit anti-PDI antibody (#bs-0295G-HRP) from Bioss (Beijing, China)