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The underlying mechanism behind this may be that the existence of C

Lipolysis-driven efflux of fatty acids triggers TAG synthesis and causes stress of the ER and activation of June kinase pathway in the adipose tissues [112, 113]

10.1016/S0896-6273(00)80837-5 59 KhodorovaA.NicolG

For instance, trastuzumab (a monoclonal antibody) is designed to target the HER2 receptor in the case of HER2-positive tumors, where it has demonstrated a significant improvement in survival rates (disease-free as well as overall survival) in early stage and metastatic disease settings (217)