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Journal of biochemistry, 149(1), 4348

Over the past decade, a variety of protocols have been established for the differentiation of human iPSCs into hepatocytes in vitro, either through viral-based expression of major hepatic transcription factors (3,4), using growth factors (5-7), small molecules (8,9), or different combinations of growth factors and small molecules (10,11) to recapitulate major signaling pathways involved in the different stages of embryonic hepatogenesis

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This shift places intense pressure on trial design, endpoints, and execution particularly in high-competition therapeutic areas such as oncology, neurology/CNS, cardiometabolic disease, and immunology