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The study protocols were approved by the Institutional Animal Care and Use Committee of the Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences [SYXK (Jing)2017-0023]

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Andreasen, C

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To investigate the impact of HBV infection on innate immune response to bepirovirsen, WT littermate control and transgenic hTLR8 mice were infected with 1x10^11 viral genome per mouse of AAV-HBV for at least 30 days prior to study start

Interventions include statins, NAC, anthocyanins, resveratrol, curcumin, berberine, vitamins, selenium, zinc-CoQ10, nanoenzymes, SOD mimetics, NOX-ASO, hydrogen-rich water, remote ischemic preconditioning, and microcurrent vagus nerve stimulation, totaling more than 30 interventions