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J., & Bornfeldt, K

35 Cigarette smoke-induced oxidative stress plays role in enhancing inflammation by regulating redox-sensitive transcription factors, such as nuclear factor kappa-B (NF-B) and activating protein 1 (AP-1), the extra-cellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK) pathways

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These findings suggest that topiramate may exert dual effects on oxidative stress, offering neuroprotection in certain contexts while exacerbating oxidative stress under different conditions and dosages