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However, preclinical studies have highlighted several critical safety concerns, particularly regarding cell retention, biodistribution, and oncogenic risk

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This allowed a variety of boronic acids to be coupled to a model cysteine-linked aryl iodide, with the benefit that even hydrophobic moieties could be transferred to the protein surface due to the water-solubilizing effect of the boronate group

Further trials should conduct better randomization and blinding procedures, recruit more participants, and provide adequate reporting

Biochemistry Mosc 65:7576536 Harris RC, Marlin DJ, Dunnett M et al (1990) Muscle buffering capacity and dipeptide content in the Thoroughbred horse, Greyhound dog and man