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Ribonucleotide reductases

Further, we demonstrated morphine inhibits PVN Glu neuronal activity through the MOR, which in turn leads to suppression of its tonic NMDA receptor-mediated currents to DMV Ach neurons, and ultimately, the overall hypoactivity of this circuit mediates small intestinal dysfunction

3.2 Interaction of MVI with protein markers of sub-nucleolar compartments To show whether MVI can interact with markers of nucleolar compartments, namely, UBF (upstream binding factor, marker of FC), fibrillarin (marker of DFC), and B23 (marker of GC), we performed a series of experiments using the immunoprecipitation (IP) as well as pull-down techniques, immunofluorescence staining, and proximity ligation assay (PLA) (Figure 2