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While intra-tumor light delivery (interstitial PDT, I-PDT) enables treatment of deeply seated tumors or tumors exceeding 10 mm in thickness, this approach necessitates percutaneous or intraoperative implantation of optical fibers into tumor cores, which may lead to procedure-related complications including hemorrhage, infection, and tumor cell seeding along needle tracts

Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer