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Note that the therapeutic indication for all of these drugs is for type 2 diabetes, with the exception of Wegovy (2.4 mg/week of semaglutide by subcutaneous injection), which was recently approved for weight loss

Interestingly, there is evidence that photoreceptor dysfunction and apoptosis precede RPE dysfunction [33]

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Moreover, an enormous amount of time, labor, and cost are needed to optimize and improvements needed to translate each stimulus-based NM from the preclinical to clinical stage apart from endogenous triggers such as pH and temperature, as this varies depending from one person to another