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How both of these two enzymes determine substrate specificity or how their regulation takes place can provide insight for discrimination/identification of developmental and stress responses

Krischer et al

"Vitamin C." National Institutes of Health: Office of Dietary Supplements

Importantly, however, particle design governs risk: surface-displayed antigens or certain chemistries can raise immunogenicity and, in rare cases, provoke severe hypersensitivity (including anaphylaxis), whereas encapsulation strategies tend to blunt immediate antigen recognition and are therefore often safer in vivo (206, 208)

Rouar, T., Parik, P., Kucera, O., Barto, M

Exposure to pristane for 12 or 24 weeks promoted macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, as well as hypercytokinemia of IFN-, TNF-, IL-4, and IL-6