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identified ten genes through whole genome knockout screening that may modify susceptibility to cuproptosis, classifying FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1and PDHB as positive regulators, and MTF1, GLS and CDKN2A as negative regulators

ROS production and associated inflammation are closely related to aging and numerous chronic diseases as diabetes, cardiovascular atherosclerosis-related diseases (144, 145) and respiratory diseases, known risk factors for developing severe illness and death in patients with SARS-CoV-2 and COVID-19 disease