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Description

Doses and pretreatment times for JMV2959 and PF-5190457 were chosen based on previous literature [12, 26, 66]

Stephen A

& Csiszar, K

both the sugar and the internucleoside linkage, i.e., the backbone, of the nucleotide units are replaced with novel groups, although the base units are maintained for hybridization with an appropriate nucleic acid target compound

Figure10 shows the time-line of decline and recovery of hepatic GSH after a therapeutic dose (1 g), and after 5 g, 10 g, 15 g, and 20 g doses, respectively