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Depending on the chemotherapy regimen, severe CIPN (i.e., symptoms that limit self-care activities of daily life or are life threatening), classified as grade 3 or 4, can occur in up to 35% of patients and symptoms can be so bothersome that they force dose-modifications or treatment discontinuation (Lustberg 2024

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However, the relevant mechanism of GPX3 kidney injury is still unclear

Minor scars and marks that have been stable for years begin to fade

It is important for patients to maintain muscle function and effectively manage occurrences of contractures