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Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein

Among the many signaling pathways associated with UC, abnormal activation of the PI3K/Akt signaling pathway may be one of the important mechanisms in the pathogenesis of UC, which has attracted attention for its multiple roles in regulating inflammatory responses, reducing oxidative stress, modulating apoptosis and autophagy, repairing the intestinal mucosal barrier, and maintaining the balance of gut microbiota (Figure 1)

A polygenic risk score has been developed to predict the vulnerability of G2019S carriers, and genes involving the vacuolar functions, lysosomal functions, and endocytic pathways were included (Nalls et al., 2019)

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Vitamin E or TTP deficiency induce oxidative stress in the brain

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