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Dihexa (PNB-0408) is an angiotensin IVderived peptide studied in preclinical models for its role in synaptogenesis and cognitive signaling mechanisms

As an experimental peptide , users accept a certain degree of risk and should let their provider know if they experience any adverse reactions

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To determine which proteoforms may be associated with pathological and cognitive diagnosis on a continuous scale, avoiding subjective between-class limits, parallel linear models were fit with quantification ratio of each peptide as outcome variables, and global cognition Z-score, global pathology Z-score, age at death, sex, post-mortem interval (hours) and number of years in education as explanatory variables

Given that cognitive flexibility was a central bridge node, it was possible that its impairment could have partially accounted for the broader executive function deficits observed in patients with an earlier age of onset

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