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For individuals, both adults and children, with moderate-to-severe AD, long-term use of medium-potency TCs in combination with proactive twice-weekly treatment using emollients can help minimize the risk of relapse [26]

The circadian clock and the mutation of its components lead to alteration in response to oxidative stress ( The homeostasis of ROS is tightly regulated by antioxidant systems like Nrf2 transcriptional regulation which is also dependent on the circadian clock (Stangherlin and Reddy, 2013

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