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Fries, E., Dettenborn, L., and Kirschbaum, C (2009)

In addition, the transition from laboratory-scale research to clinical application faces substantial barriers, including extensive preclinical testing to establish safety and efficacy, the complexities of large-scale manufacturing to ensure consistent quality, and the rigorous regulatory approval processes that demand considerable time and resources (Oliva et al., 2021

The single ascending dose portion of the study was designed to assess the safety and tolerability of AMG 966 at each dose level

Oral supplements face challenges in the digestive system, where absorption can be low, mainly in those with certain gut issues