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Genes producing signalling peptides with positive cognition coefficients exhibited enrichment within inhibitory interneurons (INs), namely VGF, SST and TAC1 (Fig

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The activation of the immune system against gluten peptides begins after their transfer to the lamina propria where they are deamidated by the tissue transglutaminase enzyme and subsequently bounded to human leucocyte antigens (HLAs) expressed by antigen-presenting cells (APCs), which activate the inflammatory cascade (Figure 2) (239, 240)

Some people can live active lives, never knowing they have FAI because they do not have any symptoms