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A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs

doi: 10.1210/endocr/bqab161 98 DuboisSLAcosta-MartnezMDeJosephMRWolfeARadovickSBoehmUet al

By controlling both proglycolytic and antioxidative gene sets, Notch can shield CSCs from metabolic stress

Yeast cells were incubated with diamide or DTT, then precipitated by treatment with trichloroacetic acid (TCA), and then free thiols (i.e., reduced cysteines) were modified with the alkylating agent 4acetamido4maleimidylstilbene2,2disulfonic acid (AMS)