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Statistical analysis All results are presented as means SEM

Abstract The phosphoinositide 3-kinase (PI3K)Akt axis is one of the most frequently activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal cancer (CRC)

doi: 10.4049/jimmunol.1301859 40 ShiLZWangRHuangGVogelPNealeGGreenDRet al

Results: Among 771 adolescents included in NHANES 2017-2018 [mean age 14.7 years

Additional studies also report that chronic inflammation impairs key intracellular signaling cascades, such as PI3K/Akt and mTOR, in granulosa cells, thereby promoting ROS accumulation and impairing follicular maturation (Gonnella et al., 2022)