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Similarly, PAHs (e.g., benzo[a]pyrene and dibenz[a,h]anthracene) are metabolized by cytochrome P450 (CYP450) enzymes (e.g., CYP1A1) into highly reactive benzo[a]pyrene diol epoxides (BPDE)

However, it remains unclear whether glycolysis or the PPP is the main glucose metabolic pathway during ferroptosis

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This may reflect receptor downregulation from continuous use

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