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Research has also indicated that vitamin C treatment increases hydroxymethylation in lymphoma and melanoma cells, and causes a decrease in tumor-cell invasiveness and clonogenic growth (Gustafson et al., 2015

Modifying cytokine combinations used during DC differentiation, such as supplementing or replacing GM-CSF and IL-4 with IL-15 or IFN-, can enhance DC immunogenicity and improve their capacity to prime T cells (Palucka and Banchereau, 2013)