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10.1016/j.cell.2018.08.041 Summary Keywords GLP-1, gut microbiota, microbiome, pancreatic -cells, probiotics, single-cell transcriptomics, type 2 diabetes Citation Ruchko E, Chernysheva M, Sokolov V, Starinnov Z, Sabirov M and Vasiliev A (2026) -cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota

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Maiti A, DiNardo CD, Wang S, Jorgensen J, Kadia TM, Daver NG, Short NJ, Yilmaz M, Pemmaraju N, Borthakur G, Bose P, Issa GC, Ferrajoli A, Jabbour EJ, Jain N, Garcia-Manero G, Ohanian M, Takahashi K, Montalban-Bravo G, Masarova L, Burger J, Thompson PA, Verstovsek S, Sasaki K, Andreeff M , Rausch CR, Montalbano KS, Pierce S, Kantarjian HM, Konopleva MY, Ravandi F

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Protein is in every cell in our body, and it has some very important roles: Protein is responsible for repairing cells and tissues and creating new ones

126 Bioactive oxidized phospholipids (oxPLs) bind to LRP6 in bone marrow mesenchymal stem cells (BMSCs) and induce their endocytosis, contributing to the inhibition of Wnt signalling and diminishing osteoblast differentiation ability