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3-HK directly binds NCOA4 and blocks ferritinophagy initiation To further elucidate how 3-HK modulates ferritinophagy, we investigated its impact on the interaction between NCOA4 and FTH1, an essential step initiating ferritinophagy 12

Because TBK1 is an essential autophagy-related protein which phosphorylate autophagy receptors (i.e., autophagic adaptor optineurin) to regulate the recruitment of cargo into autophagosomes (Weidberg and Elazar, 2011), it is possible that ICP34.5 could also indirectly inhibit autophagy by modulating TBK1 signaling

retrospectively evaluated liver biopsies in 29 patients (4.5% of those submitted to liver biopsy over an approximately five-year period at their institution) who had isolated, persistently raised, GGT 2 upper normal value [27]

N.et al (2006)

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