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Injectable delivery achieves tissue concentrations 10-20 times higher than topical application

Retinal ganglion cells express TrkB making them responsive to BDNF signaling critical for survival especially during stress or injury

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Research also indicates improvements to fibroblast production, keratinocyte proliferation, and overall healthier tissue remodeling post injury

Women with hormonal drivers (especially around perimenopause and menopause) should also get a hormone evaluation, since addressing underlying hormonal shifts is often part of an effective protocol