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SOD, CAT, and GSH-Px constitute a cascade antioxidant defense system (80).GPX4 has been uniquely recognized for its role in blocking ferroptosis through suppressing phospholipid peroxidation (81, 82)

Experimental models have evaluated it for cytoprotective and regenerative activities across gastrointestinal mucosa, tendons, ligaments, muscles, bone, nervous tissue, and vascular endothelium

Mei Y, Monteiro P, Zhou Y, Kim J-A, Gao X, Fu Z, et al

Another drug explored as an AD therapeutic is Axitinib, which is a small molecule tyrosine kinase inhibitor that targets vascular endothelial grown factor receptors and is used as an anticancer drug

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