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doi: 10.1200/JCO.19.01740 364 ForniGLolliniPLMusianiPColomboMP

Poorly perfused tumor regions can experience much more severe glucose depletion, with local glucose concentrations reported as low as ~0.10.4 mM in human colon and gastric cancers

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(2000) found that an upregulated effect was most marked in women, indicating gender variability, and that the effect was also genotype-dependent, occurring only in GSTM1-null individuals [116]

Dual-targeted delivery of temozolomide by multi-responsive nanoplatform via tumor microenvironment modulation for overcoming drug resistance to treat glioblastoma