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Within the brain, vascular dysfunction, pathological alterations in the cellular environment, and microcirculatory hypoxia frequently act as instigators of neuroinflammation, often interconnecting in a complex web [103,104,105]

Indeed, overexpression of human aldose reductase increased atherosclerosis in diabetic mice and reduced the expression of genes that regulate regeneration of GSH [17]

doi: 10.1155/2016/5843672 25 ChauhanPSDashDSinghR

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Therapeutic effect of antioxidants in sepsis Enzyme-based antioxidants Superoxide dismutase (SOD) SOD is a key antioxidant enzyme that has a protective role in sepsis by mitigating oxidative stress through the detoxification of superoxide anions