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doi: 10.3389/fnagi.2025.1641690 Received 05 June 2025 Revised 14 November 2025 Accepted 21 November 2025 Published 05 December 2025 Volume 17 - 2025 Edited by Francesc Xavier Guix, Ramon Llull University, Spain Reviewed by Minhong Neenah Huang, Mayo Clinic, United States Jianle Sun, Carnegie Mellon University, United States Updates Copyright 2025 Yuan, Zhang, Wu, Zhang, Bai, He, Wang and Zheng