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Metabolites were quenched and extracted using a slight modification of the protocol described (Thomson et al, 2022)

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doi: 10.1038/s41418-018-0252-y 29 TaddeiMLGiannoniEFiaschiTChiarugiP

Much of the initial focus of irAE identification and management was on rash, colitis, and endocrinopathies, in part because these are more common and in part because they can be associated with significant morbidity

Methods: We first employed a modeling selection approach to identify a mathematical model that best reproduced the observed multiphasic serum HBV kinetics from de-novo infection to a steady state of viremia in humanized mice (Hepatology

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