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Recently, as the function of IGFs has gradually been revealed, the important role that IGFs play in cancer progression has brought new hope for cancer treatment

The global prevalence of MASLD has risen from 25% in 19902006 to 38% in 20162019, and its incidence is projected to increase by up to 56% by 2030 worldwide ( The G protein-coupled estrogen receptor 1 (GPER1), identified 2 decades ago as a novel estrogen receptor, distinct from classical nuclear estrogen receptors (ERs)

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Moreover, Wnt/-catenin activation in TECs induces cellular senescence [33] and mitochondrial dysfunction characterized by mitochondrial loss, increased fragmentation, and elevated reactive oxygen species (ROS) production [34], all of which exacerbate kidney fibrosis

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doi: 10.1016/j.msec.2019.109803