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Urology (2015)

Delayed inflammation in rat meninges: implications for migraine pathophysiology

Beyond mouse and rat models, studies have also been conducted using porcine models of POF

In the blood smear, there are small, misshapen, often triangular or helmet-shaped structures (schistocytes or schizocytes)

Furthermore, short-chain fatty acids such as butyrate produced by periodontopathic bacterial metabolism may participate in upregulating ACSL4 expression through epigenetic regulation, although the underlying mechanisms remain to be further elucidated (27)