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Enhanced macrophage apoptosis and defective efferocytosis of apoptotic cells results in necrotic cell death causing heightened inflammation leading to increased smooth cell death, decreased extracellular matrix production, and collagen degradation by macrophage proteases

This protective effect is mediated through the AKT/GSK-3 pathway, highlighting RESs ability to counteract one of the key pathological processes in Parkinsons disease and prevent neuronal damage ( in vitro cellular experiment, RES has been shown to effectively prevent neuronal death in immature and mature cultured cortical neurons induced by N-methyl-D-aspartate (NMDA), a factor associated with excitotoxicity in various neurological conditions

doi: 10.1207/S15327914NC352_2

& Forney, L

incorporated into creams or serums at concentrations typically below 1%

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