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If your acne begins soon after starting a supplement, there may be a connection worth considering

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For B12, prolonged use of metformin and acid-suppressing drugs (PPIs, H2 blockers) may reduce absorption of oral B12, which is one reason injectable B12 is considered in select patients

Subcutaneous: B12 Injection Procedure Administering a subcutaneous B12 injection follows a similar process to intramuscular injections but involves injecting the B12 solution into the fatty layer of tissue just beneath the skin

It also helps reduce stress and anxiety