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BV-2 cells were treated for 15 min with various concentrations (0.02, 0.5, 2 mol/L) of the selective TRPV1 antagonist BCTC to block signaling through this receptor prior to the addition of p-aminophenol or AM404

Aspartame administered by transplacental and perinatal exposure followed by oral administration (feed) in male Sprague-Dawley rats caused malignant schwannoma and in female rats aspartame caused mammary gland carcinoma, and renal pelvis papilloma

In regard to the rate of mitochondrial ROS production, recent evidence suggests that the upper estimate of the total fraction of mitochondrial oxygen utilized that forms superoxide is ~0.15% (377)

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Typically, sulfosuccinimidyl 6-(4-azido-2-nitrophenylamino)hexanoate (sulfo-SANPAH) is used as a protein crosslinker in these gels