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Preclinical and Clinical Studies with Antioxidants Although evidence of oxidative damage in ALS pathogenesis has been largely described in the literature, all antioxidants tested in patients have so far failed, remaining unclear whether any antioxidant therapies might be effective for treating ALS

J Neurosci Res 68:6575 Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT (2011) Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

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Previous studies reported that SIPS can be triggered by oxidative stress caused by tBH and H 2 O 2 10,11

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Granitzer S, Ellinger I, Khan R, Gelles K, Widhalm R, Hengstschlger M, Zeisler H, Desoy G, upov L, ekov M, Salzer H, Gundacker C (2020) In vitro function and in situ localization of multidrug resistance-associated protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta