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Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism

A GRAS determination reflects a safety conclusion for a described food-ingredient use

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Use a PES (polyethersulfone) or PVDF membrane avoid standard cellulose acetate filters, which can adsorb significant amounts of peptide

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