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In vitro and metagenomic screens also confirm that the cutC gene is concentrated in Clostridia and related anaerobes, while cntA is found chiefly in Gammaproteobacteria

466 In Alzheimers disease (AD), mTORC1 overactivation and mitochondrial dysfunction contribute to neurodegeneration by impairing autophagy and mitophagy, increasing ROS production, reducing glucose utilization, disrupting energy metabolism, and promoting the accumulation of amyloid-beta oligomers as well as hyperphosphorylated and aggregated forms of pathological tau protein 467 (Fig