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In this study, we report that female subjects affected by Alzheimers disease in the Religious Orders Study and Memory and Ageing Project (ROSMAP) cohort exhibited more pronounced transcriptomic and metabolomic changes in the brain than their male counterparts did

Ossowska et al., 2005

The depletion of GSH also leads to glutamate-mediated iron and ROS generation, and triggers oxidative cell death

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In our study, we found that total glutathione, GSH and GSSG levels were increased in worms fed a HGD, suggesting that glucose-fed worms are experiencing oxidative stress