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In 1978, building on this discovery, Zamecnik and Stephenson 32 used specific oligodeoxynucleotide chains that target the 35S RNA of the Rous sarcoma virus to inhibit virus replication, marking a prototype for the application of antisense oligonucleotide (ASO) drugs in disease treatment

But around 2010 as Sikiric was conducting rat studies peptides came onto their radar

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found that UA acts as an antioxidant by scavenging the reaction products of peroxynitrite and CO 2 [43]

PCA exerted anti-inflammatory effects by lowering the expression of Vascular Cell Adhesion Molecule 1 (VCAM-1) and Intercellular Adhesion Molecule 1 (ICAM-1) in the aorta, inhibiting NF-B activity, and reducing the levels of soluble VCAM-1 and ICAM-1 in plasma, thereby inhibiting the development of atherosclerosis

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