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This systematic review evaluated the effects of NAC and GSH on oxidative stress and PD symptoms, comparing them with healthy controls or a placebo

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Abbreviations AA: Alopecia areata IP: Immune privilege DPCP: Diphenylcyclopropenone SADBE: Squaric acid dibutylester JAK: Janus kinase AT: Alopecia totalis AU: Alopecia universalis iPSC: Induced pluripotent stem cells MSCs: Mesenchymal stem cells CM: Conditioned media BMMSCs: Bone marrow mesenchymal stem cells ADSCs/ASCs: Adipose-derived mesenchymal stem cells HFMSCs: Hair follicle stem cells WJ-MSCs: Whartons Jelly-derived mesenchymal stem cells MHC: Major histocompatibility complex TGF-1: Transforming growth factor-1 IL: Interleukin -MSH: -melanocyte-stimulating hormone IDO: Indoleamine-2,3-dioxygenase CTLs: Cytotoxic T lymphocytes HFSCs: Hair follicle stem cells NK: Natural killer Tregs: Regulatory T cells MDA: Malondialdehyde SOD: Superoxide dismutase GSH-Px: Glutathione peroxidase SALT: Severity of Alopecia Tool CB-SCs: Cord blood-derived multipotent stem cells MSCT: Mesenchymal stem cell therapy ROS: Reactive oxygen species DPCs: Dermal papilla cells FGF: Fibroblast growth factor PDGF: Platelet-derived growth factor VEGF: Vascular endothelial growth factor IGF-1: Insulin-like growth factor-1 UCMSC: Umbilical cord mesenchymal stem cell DPLTs: Dermal papilla-like tissues MM-UC-MSCs: Minimally manipulated human UC-MSCs ADSVCs: Adipose-derived stromal vascular cells BMMCs: Bone marrow-derived mononuclear cells FSCs: Follicular stem cells AGA: Androgenetic alopecia References Lee HH, Gwillim E, Patel KR, Hua T, Rastogi S, Ibler E, et al

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Steril., 2004, doi: 10.1016/j.fertnstert.2004.07.878

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Vitamin C, also known as ascorbic acid, is a water-soluble antioxidant that can neutralize ROS in the aqueous environments of the body, such as the cytoplasm and extracellular fluids

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