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Revision received April 23, 2026

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Flanagan EW, Most J, Mey JT, Redman LM (2020) Calorie restriction and aging in humans

Upregulation of COL1A1 and FN1 genes in OA FLS and elevated levels of pro-inflammatory markers such as PGE2 , IL6 , and IL8 in mechanically loaded samples demonstrate the interchangeable influences of mechanical forces and TGF- signaling (154, 155)