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ACS Nano 6 (5), 40014012

Specifically, the guideline focuses on thyroid tumors and does not address non-tumorous nodules (such as Hashimotos disease or inflammatory conditions) or lymphomas

While KYN itself is not neuroactive, it is a branching point for two major metabolic routes: one leading to the synthesis of kynurenic acid (KYNA), which occurs in astrocytes, and another leading to the synthesis of picolinic acid (PA) and quinolinic acid (QA), occurring in microglia, with QA serving as a precursor for nicotinamide adenine dinucleotide (NAD) [25, 26]