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These include: Opiates/narcotics Antispasmodics Tricyclic antidepressants Anti-diarrheal medications like Alosetron, Lomotil and Imodium Proton pump inhibitors Cholestyramine Preventing methane SIBO relapse As discussed above, methane SIBO is generally less susceptible to relapse than hydrogen-dominant SIBO in our experience

3 In the current work, an optimized manufacturing process with improved transduction efficiencies was achieved, with mean vector copy number (mVCN) in peripheral blood 24 months after treatment of 1.992 (0.153.49, n = 16) in patients who became transfusion-independent, as compared to mVCN of 0.7 (0.31.5, n = 18) in HGB-204 and 1.3 (0.82.1, n = 4) in HGB-205

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